Non pharmacological treatment for psoriasis

Massachusetts Institute of Technology Summary: Using ultrasound waves, engineers have found a way to enhance the permeability of skin to drugs, making transdermal drug delivery more efficient. This technology could pave the way for noninvasive non pharmacological treatment for psoriasis delivery or needle-free vaccinations, according to the researchers.

Ultrasound -- sound waves with non pharmacological treatment for psoriasis greater than the upper limit of human hearing -- can increase skin hogyan kezeljük a pikkelysömör betegségét by lightly wearing away the top layer of the skin, an effect that is transient and pain-free.

In a paper appearing in the Journal of Controlled Release, the research team found that applying two separate beams of ultrasound waves -- one of low frequency and one of high frequency -- can uniformly boost permeability across a region of skin more rapidly than using a single beam of ultrasound waves.

Senior authors of the paper are Daniel Blankschtein, the Herman P. Other authors include Baris Polat, one of the lead authors and a former doctoral student in the Blankschtein and Langer groups, and Douglas Hart, a professor of mechanical engineering non pharmacological treatment for psoriasis MIT. Two frequencies are better than one When ultrasound waves travel through a fluid, they create tiny bubbles that move chaotically.

Male or female patients aged 18 years or older on the non pharmacological treatment for psoriasis of signing the ICF; 2. Signed and dated ICF obtained prior to any trial related activities; 3. Women of childbearing potential less than post-menopausal for two years should have a negative pregnancy test serum at V1 screening ; 7. Sexually active female patients of childbearing potential less than post-menopausal for two yearsmust agree to use documented means of effective birth control such as oral, transdermal, injectable or implanted hormonal contraceptives; intrauterine device, diaphragm with spermicide, use of a condom by the sexual partner or sterile sexual partner during the course of the treatment phase; local requirements on contraception are to be followed; 8. Patients who are capable of understanding and willing to give signed informed consent prior to any protocol specific procedure and are able to complete the trial and comply with protocol instructions.

Once the bubbles reach a certain size, they become unstable and implode. Surrounding fluid rushes into the empty space, generating high-speed "microjets" of fluid that create microscopic abrasions on the skin.

In this case, the fluid could be water or a liquid containing the drug to be delivered.

The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This article has been cited by other articles in PMC. Abstract Psoriasis is a chronic inflammatory skin disease characterized by circumscribed, red, thickened plaques with overlying silvery white scales. It is associated with the release of pro-inflammatory mediators that lead to the development of edema and distress.

However, those systems usually produce abrasions in scattered, random spots across the treated area. In the new study, the MIT team found that combining high and low frequencies offers better results.

The high-frequency ultrasound waves generate additional bubbles, which are popped by the low-frequency waves. The high-frequency ultrasound waves also limit the lateral movement of the bubbles, keeping them contained in the desired treatment area and creating more uniform abrasion, Schoellhammer says.

Clinical trials

The researchers tested their new approach using pig skin and found that it boosted permeability much more than a single-frequency system. First, they delivered the ultrasound waves, then applied either glucose or inulin a carbohydrate to the treated skin. Glucose was absorbed 10 times better, and inulin four times better. Noninvasive drug delivery Such a system could be used to deliver any type of drug that is currently given by capsule, potentially increasing the dosage that can be administered.

It could also be used to deliver drugs for skin conditions such as acne or psoriasis, or to enhance the activity of transdermal patches already in use, such as nicotine patches. Following ultrasound treatment, improved permeability can last up to 24 non pharmacological treatment for psoriasis, allowing for delivery of insulin or other drugs over an extended period of time.

Such devices also hold potential for administering vaccines, according to the researchers. It has already been shown that injections into the skin can induce the type of immune response necessary for immunization, so vaccination by skin patch could be a needle-free, pain-free way to deliver vaccines. This would be especially beneficial in developing countries, since the training required to administer such patches would be less intensive than that needed to give injections.

The Blankschtein and Langer groups are now pursuing this line of research.

What is Psoriasis and the Best Psoriasis Treatment at Mayo Clinic

They are also working on a prototype for a handheld ultrasound device, and on ways to boost skin permeability even more. Safety tests in animals would be needed before human tests can begin.

The U. Food and Drug Administration has previously approved single-frequency ultrasound transdermal systems based on Langer and Blankschtein's work, so the researchers are hopeful that the improved system will also pass the safety tests.

The research was funded by the National Institutes of Health.

• WOCBP must agree to use effective contraception, defined as oral contraceptives with one barrier method, or tubal ligation with one barrier method or double barrier method condom plus spermicide or diaphragm plus spermicide during the study and for at least 6 months after the last dose of investigational product.
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Note: Content may be edited for style and length. Journal Reference: Carl M. Schoellhammer, Baris E. Hart, Robert Langer, Daniel Blankschtein. Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound.